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These doses assume a 2 mg/mL concentration vial using an insulin syringe marked in units

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Gastrointestinal effectsparticularly nausea, vomiting, diarrhea, and constipationaffect 40-50% of patients, especially during dose escalation

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Phase Early escalation Weeks 5-8 Weekly Dose 4 mg Notes Step up every 4 weeks

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