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Thus, by increasing the excitatory drive onto thalamic neurons, the burst-firing of thalamic relay neurons can be prevented

Alternative integrin signaling IGF not only binds to IGF-IR/InsR, but also directly binds to other receptors such as integrin, a family of adhesive receptors that promotes cancer stemness and cell survival to adapt to environmental and therapeutic stresses [170, 171]

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Transcription factors like SOX9 can drive the establishment of a stem cell-like transcriptional state, directly leading to platinum resistance in ovarian cancer [72]