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Eguia RT, Crawford K, Stevens-Ayers T, Kelnhofer-Millevolte L, Greninger AL, Englund JA, et al

This requires a set of tools in addition to bacteriostatic water , such as sterile vials, insulin syringes, and other materials

The general procedure followed in the laboratory for this type includes reconstitution with bacteriostatic or sterile water, storage of the lyophilized powder under cool and dark conditions, and storing the reconstituted solution under cold temperatures to avoid repetitive freeze-thaw cycles and light

In some embodiments, the otoprotectant is a compound of Formula (V): wherein: R 1 is C 6 -C 10 aryl or C 3 -C 9 heteroaryl, wherein C 6 -C 10 aryl and C 3 -C 9 heteroaryl are optionally substituted with one or more R 4

This suggests that components involved in TJ disassembly may represent useful therapeutic targets by limiting the impact of enteric pathogens on intestinal barrier integrity and restricting their systemic spread

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