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Nuclear factor kappa B: a pro-inflammatory, transcription factor-mediated signalling pathway in lung carcinogenesis and its inhibition by nonsteroidal anti-inflammatory drugs

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Like Cagri-CTR-Gs complexes, CagriBB-CTR-Gs complexes could also be resolved into two major clusters based on the Cagri conformation: bypass (80%), CT-like (20%)

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Defects in complex I are among the most common causes of mitochondrial diseases, contributing to disorders such as Leigh syndrome, mitochondrial encephalomyopathy and Parkinsons disease by disrupting ATP production and elevating oxidative stress 21,71,72,73