Although the colorimetric change that occurs following LPL-mediated hydrolysis of PNBP provides a convenient way of assessing LPL-mediated hydrolysis, using PNBP as a substrate to measure LPL activity in biological samples is not physiologically relevant since PNBP prevents LPL-mediated TG hydrolysis, and the hydrolysis of PNBP itself is inhibited, rather than activated by, ApoC-II (83, 85)
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This targeted delivery aims to maximize therapeutic effects by delivering both drugs to the affected psoriatic skin layers, potentially offering a more effective treatment strategy (116)
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