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At the cellular level, under hypoxic conditions, the hypoxiainducible factor (HIF)prolyl hydroxylase family of enzymes (PHD13) lose their ability to hydroxylate HIF because they rely on O 2 for their enzymatic activity [139]

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Since the intestinal Ca 2+ absorption is an active process, which requires ATP that is mainly provided by the mitochondria, we have analyzed the functionality of these organelles in the intestinal mucosa when animals were treated with MEN

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