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Risks include: Contamination with bacteria or fungi Endotoxin (bacterial cell wall fragments) that remain even after sterilization Severe inflammatory reactions or sepsis D

Cultured human keratinocytes have been suggested as good models to predict dermal irritancy of substances in human subjects 31

At 10 mg in 2 mL, the solution is 5 mg/mL

For lyophilized powder with unknown exposure, visual inspection is the deciding factor white powder with no discoloration is likely salvageable

Because it's investigational and potent, its long-term human safety isn't fully established

Among patients without Laron syndrome, the mean height SDS at baseline was 3.6 (SD = 1.1)