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High-dose anthocyanin treatment (200 mg/kg) increased serotonin levels and reduced oxidative stress (H 2 O 2 ), elevated the expression of microRNAs (miR-145-5p and miR-451a), and suppressed spinal neurone degeneration, TNF-, and caspase-3 activation
This study was important as there had been no previous reported data on the possible effects of hepatic impairment on the pharmacokinetics of SNAC, which is metabolized via -oxidation and glucuronidation and is highly bound to albumin
This effect seems to occur independently of the liver level status of the lambs
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