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b , c ) Smad3 gene expression levels in iSPN + at 3 M (Control vs Mutant, p = 0.2) and 8 M (Control vs Mutant, p = 0.004 **)

Although ligand-receptor pathways are often thought of as linear paths from engagement to transcription/translation, many studies show that enhanced oxidative potential can augment or suppress signaling pathways, including those related to MUC5AC, while more recently, oxidatively driven epigenetic effects on gene transcription have also been reported (2932)

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If previous exposure to copper has caused allergic reactions, avoid this peptide entirely

10.1186/s10020-024-00873-0 294 LuL.LiW.SunC.KangS.LiJ.LuoX.et al

Multiple clinical trials in photoaged skin (sun damage) have shown that topical GHK-Cu formulations improve skin appearance including reductions in fine lines and wrinkles, improvement in skin firmness and elasticity, enhancement of skin texture and smoothness, increase in skin thickness (reversing age-related dermal atrophy), improvement in skin clarity and reduction in hyperpigmentation, and overall rejuvenated appearance