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Second, the underlying molecular processes behind the occurrence of distant metastasis, dormancy, and late-stage disease recurrence, especially in hormone receptor-positive breast cancer, are not fully understood, making it difficult to develop efficient metastasis-preventive therapies (327)
10.1016/j.redox.2021.102010 14 IsingC.VenegasC.ZhangS.ScheiblichH.SchmidtS
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In the case of miRNA therapies in RA, local delivery (intraarticular) might be beneficial, because a greater amount of active substance might reach the site of RA progression and possible systemic effects of miRNAs could be reduced
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