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In phase 3 trials, after 56 weeks of treatment, 62% of patients receiving contrave 32 (bupropion SR 360 mg/naltrexone SR 32 mg) lost at least 5% of their body weight as compared to 23% of patients in the placebo group [240]

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AS-IV modulates the Akt/PDE3B pathway to inhibit cAMP accumulation, thereby suppressing lipid catabolism, which is beneficial for limiting liver lipid deposition and reducing excessive hepatic glucose production (Zhou et al., 2017)

Neuroendocrine regulation of eating behavior

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