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Pharmacy benefit managers (PBMs) favor high-list-price originators for rebates, inflating costs and hindering biosimilars (e.g., slow adalimumab uptake in the US)

So obesity, which is what we define as having excess body fat or excess adiposity, is a chronic medical disease and unfortunately leads to many different downstream problems

Qiu W, Hu M, Sridhar A, Opeskin K, Fox S, Shipitsin M et al

Pharmaceutics, 17 (4), Article 397

Further, chronic activation of GABAergic vlPAG neurons causes marked weight loss in diet-induced obese mice due to both a suppression of food intake and an increase in energy expenditure [115]

In the Th17/Treg balance, Th17 cell polarization is a key driver of inflammation