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SGLT2 inhibitors in the treatment of diabetic kidney disease: more than just glucose regulation

Partially supported by Instituto Nacional de Psiquiatra Ramn de la Fuente Muz

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The presence of a compromised intestinal barrier known as leaky gut is supported by several studies that have found higher levels of LPS and antibodies against LPS in the peripheral blood of ME/CFS patients than in controls [75,78,102,103]

Plasmid for single-stranded adeno-associated viral vectors 2/8 The plasmid pAAV-MCS-hAAT/EGFP was designed for maximum transgene expression and includes the hepatic locus control region from the ApoE gene (ApoE-HCR), a liver-specific 1-antitrypsin promoter (hAAT promoter), coagulation factor IX intron A (FIX intron A), a 3' mRNA transcription termination/polyadenylation signal (bghpA), and a reporter gene encoding enhanced green fluorescent protein (EGFP), as previously described (Miao et al