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We uncover a novel mechanism by which estrogen regulates ferroptosis in ER+ breast cancer (Fig

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The addition of exogenous ROS results in resensitization of cells with high VRK2 expression to GSH inhibition, which is consistent with the fact that PC cells with low expression of VRK2 are susceptible to GSH inhibition attributes to its high basal ROS level, suggesting that cells in a state of oxidative stress have enhanced dependence on the GSH system

Ruxolitinib (Opzelura) is a newer medication approved by the FDA in 2022 to restore lost skin color in people with vitiligo

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Maintaining healthy levels helps prevent the build-up of hormone byproducts and reduces the oxidative stress that disrupts hormone-producing glands