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Description

J Pharmacol Exp Ther 2012;340:539-48

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Weeks 4 to 8: Improvements either plateau or persist

Cell 156 , 730743 (2014)

Recommended transition protocol: Complete the final tirzepatide dose Wait 7 days Start semaglutide at 0.5 mg (not 0.25 mg, because the patient is already GLP-1 adapted) Escalate to 1.0 mg after 4 weeks, then 1.7 mg, then 2.4 mg Starting at 0.5 mg rather than 0.25 mg reduces the total titration time and is well-tolerated in patients already on tirzepatide