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Starting at 250-300mcg regardless of body weight, then adjusting based on response, often works better than jumping to weight-based higher doses

Nat Metab (2023)

These effects are typically less common than gastrointestinal effects but should be reported to your provider if they persist or worsen

The FDA has never approved this combination, and cardiology literature documents increased rates of arrhythmias and hypertensive episodes in patients attempting dual therapy

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Of course, it cannot make a miracle but it might have some effect via regulating microcirculation and normalizing the metabolism in the cells of connective tissues