The broader enforcement focus: Botox-type products, ophthalmics, clinical trials, recalls The RAPS article also highlights other key enforcement priorities for CDER in 2025: The agency issued 18 warning letters to firms marketing fraudulent or unapproved Botox-type products, warning that such products pose serious safety risks, including potential counterfeiting, incorrect/inactive ingredients, or falsification
Given the banal nature of supplementation, in addition to the low cost, our clinicians advocate supplements in some cases of melasma, pigmentary disorders & skin lightening
Clinically, bone density can be assessed by dual-energy x-ray absorptiometry (DEXA), with interpretation used to diagnose or assess risk of osteoporosis
PRKAR1A mutations and loss of PRKAR1A protein expression are seen in most cases and should prompt a search for other findings of the Carney complex [3, 4]
This makes them appealing to people with sensitive skin or those looking for gentler anti-ageing options
Acknowledgements The current research was funded by the European Union Seventh Framework Programme HeCaToS (FP7/2007-2013) under the Grant Agreement No