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Moreover, these HLCs displayed significant CYP450 metabolic activities for CYP3A4, CYP2C9, and CYP2D6, similar to PHs

This effort led to the development of Dihexa (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide), a key focus of this study [2]

PMCID: PMC8524106

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2) This review completed by Wright et al investigates the development of small molecule AngIV analogs as potential treatments for AD and PD, two debilitating neurodegenerative conditions currently lacking effective disease-modifying therapies