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The concomitant administration of -tocotrienol has demonstrated an increased efficacy of gemcitabine (88), and a phase I study on pancreatic cancer patients was conducted with escalating doses of -tocotrienol in the 2 weeks before surgery (91)

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In both of these studies, CagriSema was well-tolerated with an acceptable safety profile, with similar results reported in a phase 1b study in participants with overweight or obesity [7] and a phase 2 study in participants with type 2 diabetes [4]