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A 2025 body-composition substudy added detail on fat-mass versus lean-mass changes within the T2D Phase 2 cohort fat mass accounted for the majority of total weight reduction (PMID 40609566)

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If the 4 mg maintenance arm proves non-inferior for weight maintenance in Phase 3, researchers may be able to titrate up to a high working dose during the active weight-loss phase, then step back down to a lower 4 mg maintenance dose for the long stabilization phase

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El descubrimiento de su funcin ha revolucionado el tratamiento de la diabetes tipo 2 y la obesidad, dando lugar a medicamentos innovadores que imitan su accin