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Sensitivity Analysis and Meta-regression Analyses Intertrial heterogeneity was detected across the studies for HbA1c change

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This leads to: More glucose remaining in circulation after meals More insulin release to compensate More energy stored as fat initially subcutaneous, but eventually as visceral fat As VAT accumulates, it drives inflammation, insulin resistance, and metabolic dysfunction creating a vicious cycle

Many people find that this "two-pronged" approach provides the most comprehensive cellular support.