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During the revision of this manuscript, a crystal structure of TMEM55B was published, and TMEM55B was identified as a central hub for adaptor recruitment on lysosomes, binding various clients via a TMEM55B-binding motif (TBM) 34,55

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GH is produced by the pituitary gland, which is under the positive control of the hypothalamic peptide GH-releasing hormone (GHRH) and the negative feedback of somatostatin

V ss , volume of distribution (steady state)

Although this study has systematically elucidated the therapeutic efficacy and mechanisms of GPS in various diseases, its clinical translation still faces significant challenges