Fatemi, S
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Food intake remained consistent between the groups, suggesting metabolic changes
However, it remains under investigation whether these benefits are directly due to the GLP-1 agonists or a result of the weight loss they facilitate
Sensitivity or Allergies to B12 or Its Components: Some individuals may have an allergic reaction to the preservatives or additives in B12 injections, especially those with known sensitivities to certain medications or substances
Phase 1a: First-in-Human Single Ascending Dose Study (NCT02951806) Study Title: "Safety, Tolerability, and Pharmacokinetics of Single Doses of Cagrilintide in Healthy Subjects" Status: Completed Phase: Phase 1a Enrollment: 48 healthy volunteers Study Period: 2016-2017 Location: Single center (Denmark) Design: Randomized, double-blind, placebo-controlled, single ascending dose Dose Range: 0.03-10 mg SC Primary Endpoints: Safety, tolerability, PK parameters Population: Healthy male subjects, BMI 20-28 Key Results: Pharmacokinetics: Terminal half-life 5-7 days across dose range