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The transition period, which can last several years, typically represents the peak of nausea symptoms

Introduction: The Testing Framework for Nasal Drug Products Nasal sprays are a clinically important and commercially significant dosage form delivering active pharmaceutical ingredients directly to the nasal mucosa for local effects (treating allergic rhinitis, nasal congestion, sinusitis) and systemic absorption (delivering drugs via the highly vascularized nasal epithelium, bypassing first-pass hepatic metabolism)

Dvergsten CL, Johnson LA, Sandstead HH

doi: 10.1016/j.ecoenv.2021.112947 150 YuanATStillmanMJ

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Simonsen MH, Erichsen R, Froslev T, Rungby J, Sorensen HT