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Leptin is also involved in the effects of CRF and the urocortins as demonstrated by the fact that the anorexigenic actions of leptin are attenuated in the presence of CRF antagonists

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[71] [72] Research [edit] In a phase III trial, tirzepatide demonstrated clinically significant benefits among participants with obesity and heart failure with preserved ejection fraction

Large-scale projects such as The Cancer Genome Atlas (TCGA) (270), Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) (271), International cancer genome Consortium (ICGC) (272), Pan Cancer Analysis of Whole Genome (PCAWG) (273), National Cancer Institute-Clinical Proteomic Tumor Analysis Consortium (NCI-CPTAC) (274), and Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT) (275) have generated high-resolution datasets that include bulk gene expression data, somatic mutations, Copy Number Variations (CNVs), methylation patterns, cell-type-specific gene expression profiles, acetylation, and phosphorylation across thousands of samples collected from diverse races and geographical locations

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