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Neurol Sci

In a clinical study by Kerttula et al

Furthermore, FGF21 exerted its neuroprotective and antioxidant effects, at least partly, through inhibiting the protein degradation of SLC25A39 mediated by AFG3L2

(2003) Functional analysis of a phosphatidic acid binding domain in human Raf-1 kinase: mutations in the phosphatidate binding domain lead to tail and trunk abnormalities in developing zebrafish embryos

This is due to the fact that M1 macrophages, which are pro-inflammatory, possess higher concentrations of inducer nitric oxide synthase (iNOS), leading to a greater production of nitric oxide free radicals and stronger protection against lipid peroxidation, when compared to M2 macrophages, which are anti-inflammatory and have lower iNOS concentrations (83)

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