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Those in the trial that did experience negative side effects did so at the same rate and consistency as those previously reported for injectable GLP-1 drugs and Eli Lilly said it "was consistent." The drugmaker said the most commonly reported negative side effects were mild to moderate gastrointestinal-related symptoms, such as nausea, constipation, indigestion, diarrhea and vomiting

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The primary safety concern during early GLP-1 treatment is gastrointestinal side effects such as nausea, which can intensify with vigorous exercise on a full stomach

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6 Bone metabolism Individuals with PWS typically have a bone structure characterized by short stature, low bone mineral density (BMD), and low bone mineral content (BMC) (74), often leading to orthopedic issues such as scoliosis, kyphosis, hip dysplasia, flat feet, and genu valgum (75, 76)