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Similar patterns of cellular damage are observed in both metabolic disorders and PD, including mitochondrial dysfunction, impaired autophagy, oxidative stress, endoplasmic reticulum stress, and gut microbiota alterations

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We also observed increased aggregate formation following incubation of the GST fusion proteins with cell lysate, which appears to depend on both the cell type and experimental conditions

Preliminary human studies suggest a favorable safety profile, though clinical efficacy data remain limited

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