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Conversely, in another phase 2b study involving patients with T2DM, tirzepatide showed significantly better efficacy in glucose control and weight loss compared to both placebo and dulaglutide, with an acceptable safety and tolerability profile (111)

That does not mean patients should change doses on their own

PMID 24112036

However, this future weight loss drug distinguishes itself by also acting on receptors for a third hormone called glucagon, which plays a role in regulating hunger

That is why these two names keep showing up together

To measure the insulinotropic effects of GLP-1 (7-37) in a physiologically relevant animal model, Habener reached out to his friend Gordon Weir, an endocrinologist based at the Joslin Diabetes Center and Harvard Medical School