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It is important that dermatologists know about glutathione: its efficacy, the mechanism of hypopigmentary effects, pharmacokinetics, evidence-level and safety profile

Marras TK, Sanders K, Lipton JH, Messner HA, Conly J, Chan CK

Binding/competition metrics in receptor systems (e.g., IC50/Ki where applicable) Second-messenger readouts (assay-dependent) Pathway readouts (e.g., phosphorylation markers) in controlled cell models (assay-dependent) Receptor trafficking/internalization (imaging or tagged-receptor assays) Stability/integrity profiling (e.g., HPLC profiles

The expression of the epithelial-mesenchymal transition transcription factor Snail leads to Scrib displacement from the plasma membrane to the cytosol, which is associated with disrupting S -palmitoylation of Scrib in epithelial cancer cells (77)

Gardner DM, Murphy AL, ODonnell H, Centorrino F, Baldessarini RJ

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