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Contraindicated in uncontrolled hypertension, cardiovascular disease, pregnancy, and breastfeeding

[7] [14] Participants receiving higher doses of retatrutide (particularly 8 mg and 12 mg weekly) experienced mean increases in heart rate of approximately 5 to 7 beats per minute (bpm) above baseline, based on data reported in the 2023 NEJM Phase 2 publications

Future Directions and New Treatments Newer medicines and combinations are being developed which act at glucagon and amylin receptors

Retatrutides impact on lipids is particularly striking due to the glucagon receptors influence on the liver

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