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Consistently, HIF1A also promotes GSH synthesis through transcriptional activation of GCLM and SLC7A11 , and pharmacological inhibition of SLC7A11 with erastin or sorafenib exacerbates cuproptosis 177,178

Samudio I, Harmancey R, Fiegl M, Kantarjian H, Konopleva M, Korchin B et al

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Despite seeing multiple doctors and trying different diets, I felt alone and frustrated

128 The authors concluded that TSN induced ferroptosis both in HepG2 cells and in vivo