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Sub-therapeutic doses may provide insufficient pharmacological activity

doi: 10.3389/fcell.2019.00182 54 MendizabalIZengJKellerTEYiSV

The minimum effective dose has been a cornerstone of medicine for decades

Phase advancement, amplitude reduction, or decreased stability of the prolactin circadian rhythm (e.g., the prolactin peak occurring earlier than the cortisol peak) may promote fat accumulation and metabolic abnormalities (75)