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I 2 0%), and angina pectoris (RR 0.77, 95% CI 0.600.98)

If the ANDA or 505(b)(2) NDA applicant has provided a paragraph IV certification the applicant must send notice of the paragraph IV certification to the NDA and patent holders once the application has been accepted for filing by the FDA

This makes them a potential new strategy for preventing and treating AD, though their mechanisms of action and specific molecular pathways remain unclear

This evidence gap is the single largest limitation of peptide-based approaches