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Very short plasma half-life (minutes)

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ScHyr1 acts as a hydroperoxide sensor, forming a disulfide bond with Yap1, and thereby masking a Yap1 nuclear export signal 59,60

We dont know yet if immune responses to peptide sequences will mean its less effective over time or causes systemic symptoms

People taking heartburn medication, such as proton pump inhibitors, are at a higher risk for B12 deficiency and may benefit from alternative therapies to control/eliminate the heartburn or have regular Nutrient IV therapies and/or Vitamin B12 injections Elderly Vegans Vegetarians People with tapeworms Alcoholics Excessive use of antibiotics Excessive use of anti-convulsant medication Daily consumption of Aspirin may increase the risk for vitamin B12 deficiency

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