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Variants in GLP1R (the GLP-1 receptor gene that every GLP-1 compound targets), FTO (the fat-mass and obesity-associated gene), MC4R (a melanocortin receptor central to satiety), and TCF7L2 (a transcription factor tied to glucose homeostasis) describe the terrain a clinician prescribes into

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These appraisals emphasise an evidence-based, whole-person approach to treatment

Topical tretinoin needs frequent application for long duration (2 months) and improves hyperkeratosis, but not hyperpigmentation