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They also trigger the release of insulin from the pancreas and inhibit the secretion of glucagon, a hormone that raises blood sugar levels

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In individuals with T2DM, chronic hyperglycemia is known to downregulate GIPR expression and impair GIP-stimulated insulinotropic activity, thereby limiting the efficacy of GIP monotherapy [21]

That can be a good thing for your blood sugar level (fewer big meals means fewer blood sugar spikes), but it can also introduce an additional challenge: eating enough nutrients to protect your heart health, muscle mass, and metabolic health

CONTRAVE should be used with a reduced-calorie diet and increased physical activity