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Appetite can become very low during titration

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But you should reach out to your prescribing physician if you experience any of the following: Symptoms that are severe or worsening after two weeks at the same dose Signs of dehydration such as dark urine, dizziness, dry mouth, or rapid heart rate Blood in your stool or severe abdominal cramping Inability to keep food or fluids down Fever accompanying your symptoms Your provider can slow your dose escalation schedule, temporarily reduce your dose, or recommend supportive medications