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Clinical studies indicate that noninvasive multi-metabolite profiling of spent embryo culture medium can stratify implantation potential: spectroscopy-based approaches typically yield ~7080% overall predictive, whereas targeted liquid chromatography-mass spectrometry (LC-MS) models built from a small set of metabolites have achieved an area under the receiver operating characteristic curve (AUC)0.88 [66, 415, 416]

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