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Although there are slight short-term differences, there is no evidence to suggest long-term changes in performance

It has passed phase 1 and 2 clinical trials and is currently in phase 3 trials, with an expected launch in 2026 or 2027 if approved

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Jacobsen, "Identification of Multiple Proteins Coupling Transcriptional Gene Silencing to Genome Stability in Arabidopsis thaliana", PLOS Genetics DOI:10.1371 (pgen1006092 20 pages): (2016)

Further studies revealed that other bacterial species encode YopJ-family members acting as pure DUBs cleaving Ub chains with various preferences for different linkage types or ULPs, i.e., acting as isopeptidases to cleave SUMO chains, NEDD8 chains and/or ISG15 chains 26,33,44