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It's whether the experimental design isolates each compound's contribution, controls for confounding variables, and monitors the right endpoints

G., Jin, Y., Bunney, B

Definitive evidence of the role of FFAs in GH-mediated insulin resistance was obtained in clinical studies in which the effects of exogenously administered GH on insulin resistance were abrogated by Acipimoxan inhibitor of lipolysis [185, 190, 191]