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Expect an adjustment period as you titrate to semaglutides maintenance dose, with full additional benefit becoming apparent over several months

Trulicity costs $987/month vs Zepbound's $1,086/month at list price in 2026

These were generally mild to moderate in severity, most prominent during the dose escalation phase, and tended to diminish over time

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The absence of pharmacokinetic studies, dose-response relationships, or comparative effectiveness data represents a significant evidence gap

Forcing the next dose increase while still symptomatic nearly always makes things worse and can lead to protocol abandonment, which defeats the entire purpose of careful titration