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Quick Answer: GLP-1 probiotics typically cause mild gastrointestinal side effects such as bloating, gas, and temporary digestive changes, though serious risks exist for immunocompromised individuals

Pooled analysis including these two studies in addition to SELECT and FLOW [31] reported that semaglutide reduced the risk of hospitalization or urgent visits due to heart failure by 41% (HR 0.59, 95% CI 0.410.82) in HFpEF patients compared with placebo [32]

Compounded GLP-1s are not reviewed by the FDA for safety, efficacy, or quality, and may not be available in all states

Microbiota composition affects insulin sensitivity

Most people notice increased appetite suppression within one to two weeks of the switch, sometimes with a temporary increase in GI side effects as the body adjusts to the dual agonist