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reported that liraglutide and exendin-4, respectively, attenuated self-administration and reinstatement in these rodents, while repeated administration of GLP-1RAs reduced the occurrence of withdrawal-induced hyperphagia and post-smoking cessation weight gain [20, 21]

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We discovered a highly active GLP-1 analogue in which the native glutamate residue three positions from the N-terminus was replaced with the sulfo-containing amino acid cysteic acid (GLP-1-CYA)

Most benefits appear in patients with insulin resistance or prediabetes, where normalizing glucose dynamics has secondary weight-management effects

Understanding Tirzepatide: A Quick Refresher Before we dive into the reconstitution process, let's quickly re-establish what we're working with