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Outcome definition The primary outcome was time to initial GLP-1RA prescription following the index diagnosis of T2DM

Clinical practice guidelines[20, 21] have recommended the use of SGLT2i in individuals at higher risk of HF, while GLP-1RA may be prioritized in those with T2DM at higher ASCVD risk (calculated 10-year ASCVD risk 10%, Class IIa, level of evidence: B) given their neutral effect on HF hospitalization [22]

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Wakabayashi N, Skoko JJ, Chartoumpekis DV, Kimura S, Slocum SL, Noda K, et al

Stay hydrated: Drink water regularly throughout the day to help prevent fatigue

Second, head-to-head trials of various GLP-1 RA treatments (including more recent dual and triple agonists) with prospectively specified inflammatory and oxidative stress biomarker endpoints should be part of future comparative efficacy studies