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Figure 1 4.1.1 Cardiovascular outcomes in SGLT2 inhibitors: safety studies The EMPA-REG OUTCOME trial, which included 7020 patients with T2DM, was the first to demonstrate the cardiovascular protective effects of empagliflozin (54, 56)

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The ongoing REMAIN-1 trial is designed to test whether this renewal of the intestinal lining can trigger a lasting metabolic reset, helping the body maintain weight loss after stopping medications like semaglutide or tirzepatide

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Retatrutide creates the perfect environment for fat loss through appetite suppression, improved insulin sensitivity, and increased energy expenditure

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