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10.1016/j.jep.2012.03.038 78 PiverB.BerthouF.DreanoY.LucasD
Discussion Here we report the development of a unimolecular quintuple agonist that combines the body weight and blood glucose-lowering effects of GLP-1GIP co-agonism with the insulin-sensitizing and anti-inflammatory properties of the nuclear-acting PPAR// triple agonist Lani through targeted delivery into cells expressing GLP-1R and/or GIPR
[7] Use in pregnancy and breastfeeding is of unclear safety
Why does non-selectivity limit its use as a research tool
[1] Its the same method used for nicotine and birth control patches
