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doi: 10.1016/j.ejphar.2019.172593

Thats not an in vitro petri dish

Novel SIM1 variants expanding the spectrum of SIM1-related obesity

General advice is not good enough when you are working with compounds that affect gene expression at the cellular level

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22 These findings illustrate the progressive efficacy observed with increasing receptor engagement, while underscoring the need for cautious interpretation across heterogeneous study designs