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Teach patients to recognize and report warning signs: Serotonin syndrome: agitation, confusion, rapid heart rate, elevated temperature, muscle rigidity Hypertensive crisis: severe headache, chest pain, vision changes, nosebleed Remind patients not to share medications with others, and to store and dispose of them properly (especially phentermine, given its controlled status)

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Therefore, additional, high-quality research would be needed to allow definite conclusions to be reached about whether berberine reduces weight and BMI

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Rashed MS, Ozand PT, Bennet MJ, Barnard JJ, Govindaraza DR, Rinaldo P

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