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Results of repeated measures linear mixed effect models indicated a significant interaction between group and time for BrAC ( 2 (7) = 16.36, p = 0.022, f = 0.36)

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Hirvonen, K., Bai, Y., Headey, D

Three designed analogues incorporated diselenide bonds at the native cross-links (614, 1628, and 2239), while a fourth analogue introduced a diselenide bridge at a non-native position (616), based on the proposed role of this non-native disulfide bond in the early stages of hirudin folding